For decades, this storefront was home to Gem Spa (RIP May 2020). Workers have uncovered some local ephemera on the front pillars (as we noted here).
The latest reveal ... a flyer for Stuyvesant Casino, a nightclub located in what is now the Ukrainian National Home at 140-142 Second Ave. between St. Mark's Place and Ninth Street from 1910 to the 1950s... (thanks to Kevin Goodman for this shot...)
Per this NYSMusic site: "The Stuyvesant Casino offered sumptuous food, dazzling decor, and a first-class house band. High rollers and hitmen were among the clientele, particularly Big Jack Zelig, head of the Eastman Gang after the death of 'Kid Twist' Max Zwerbach, in 1908."