The three-story building — aka the San Isidoro y San Leandro Western Orthodox Catholic Church of the Hispanic Mozarabic Rite — on Fourth Street between Avenue C and Avenue D is for sale.
The listing for the address describes it as a "religious building" and "former religious assembly space" with potential use as either a single-family home or multiple units. There are unused air rights too.
Here's more about the sale via Cushman & Wakefield:
[T]he building sits on a 24’ x 96’ lot and contains approximately 4,502 SF above grade or 6,810 SF with usable lower level. 345 East 4th Street is in an R8B zone which allows for a total BSF of 9,232 (approximately 4,730 SF of unused air rights are intact).
A new development (of 9,232 SF) could be residential single family/multi-family or Community Facility. The building was formerly used as a religious assembly space and will be delivered vacant upon sale.
It is currently configured with a step-down usable lower level, a former religious assembly space with soaring ceiling height on the first floor which includes mezzanine space, and an owner’s apartment on the top floor. The lower level previously housed building mechanicals but is now used for general storage and can be accessed directly from the street or from the first floor. Lower level and first floor are built full on the lot while the top floor is approximately 51’ deep.
The former religious assembly space benefits from tremendous ceiling heights (20+’) and therefore lends itself well to a user looking for interesting space. The owner’s unit has four rooms plus a kitchen, full bathroom and outdoor roof space. Due to the impending vacancy, the property presents an exceptionally unique opportunity for a developer and/or end user.
Price: $6 million.
According to New York City Songlines, the San Isidoro y San Leandro Western Orthodox Catholic Church of the Hispanic Mozarabic Rite is "named for brothers who were successive bishops in Seville, circa 600 AD. Originally a Russian Orthodox Church, built circa 1895." I do not know when the church last held any type of mass here.
Here are two photos of the interior that I took in 2011 during one of the many weekend rummage sales held here...
... and here's an interior shot via the Cushman & Wakefield marketing materials...
According to public records, Patricio Cubillos Murillo (there are several variations of this name) is the building's owner, with a deed dating to September 1975.
The document on file with the city shows that this building changed hands for $6,000 that year. Here's the first page...
[Click on image for more detail]