[Updated: Sorry, I had "South American" restaurant rather than Southern American]
Amaya thai eatery on Fourth Street near Avenue B closed last summer around this time... Workers are currently renovating the space. A few readers noted that the rumors pointed to a southern restaurant opening here.
The restaurant will be called The Cardinal, and as Eater reported, the CB3/SLA committee OK'd a beer-wine license for the place on Monday night. (A new license within a resolution area too.)
According to the questionnaire The Cardinal reps gave to CB3 (PDF here), the restaurant will serve Southern American Cuisine ... the place can seat 74 people. No word just yet who the owners are here.