As I cut-n-paste from the Internet: "It is set in the Marvel Cinematic Universe, sharing continuity with the films of the franchise. The series takes place after the events of the film 'Avengers: Endgame.'"
Anyway, it promises to be a big shoot tomorrow... with production vehicles expected on an array of side streets... from Fourth Street to 10th Street and First Avenue to Avenue C... check out the streets on the posted move-your-vehicles notices... filming in downtown Brooklyn last week. The cast reportedly includes Hailee Steinfeld, Alaqua Cox, Tony Dalton, Vera Farmiga, Florence Pugh and Jeremy Renner.
And this is not the first time a Marvel series has been filmed in the East Village. Flashback time.