There was some speculation that the long-vacant 6 Avenue B on the NW corner might be part of a new residential project.
A little digging in public records (courtesy of Upper West Sider — thank you!) reveals that work has been filed in recent months to upgrade antennas and add new FDNY access signs at No. 6. Seems doubtful, as Upper West Side noted, that AT&T would spend the money to upgrade the equipment if the building was about to be demolished.
As for No. 6 ... the liquor store in the retail space has been closed since the owner passed away in the fall of 2009 at age 89. (Chico created the tribute to her on the gate in February 2010.)
In January 2013, workers were spotted hauling out some junk from the building... in December 2014, bricks fell from the building, breaking the foot of a passerby, as the Lo-Down reported at the time. And an SUV took out part of the sidewalk bridge in November 2018. And that's about it.
And as previously noted, this is one of the abandoned buildings owned by the estate of the mysterious team of Arthur and Abraham Blasof, now both deceased.
Updated 10:30 a.m.
Thanks to the commenter who did a little digging in the archives. There was a question about the windowless lot line at 6 Avenue B. Here's a tax photo dated 1939-1941 showing a building identified as 2-4 Avenue B (with a Circulating Library storefront!) ... that corner structure was likely demolished when the city widened East Houston... and No. 6 became the new corner building...... and the old NW corner... you can see No. 6 in the background...